Share << Previous PostNext Post >> Travelweek Group Uniglobe Travel (Western Canada) signs new franchise agreement, unveils new 9-location franchise Tuesday, April 10, 2018 Posted by VANCOUVER — Uniglobe Travel (Western Canada) is expanding its franchise volume with a new five-year Master Franchise Agreement with Uniglobe Travel (International) LP.Irv Wight, President of Uniglobe Travel (Western Canada), said this is an “excellent time” to focus on the growth of its franchisees in areas of core strength: the Leisure Traveller, SME Corporate, Groups and Independent Agents. “A new five-year agreement supports our commitment to the Uniglobe brand and our partner relationships,” he said.In addition, Uniglobe Travel (Western Canada) also announced a newly formed franchise operating under the name Uniglobe LGI Travel. This nine-location franchise encompasses the Leisure, Groups and Independent division previously operated under Uniglobe One Travel.Despite the new name, Uniglobe LGI Travel and its 35+ travel professionals all have a wealth of experience in managing groups and customized vacation packages for the past 25 years.“With an excellent team of industry leading professionals at Uniglobe LGI Travel, we are excited about our future and our plans to lead the way in new technology and revolutionary solutions to simplify the travel process for our clients and our consultants,” added Wight. Tags: UNIGLOBE
Boeing hosts China President Xi JinpingBoeing (NYSE: BA) today welcomed China President Xi Jinping to its widebody commercial airplane factory and announced several agreements that will broaden and deepen mutually beneficial cooperation between Boeing and China.The agreements include orders and commitments for 300 Boeing narrowbody and widebody aircraft and expanded collaboration between Boeing and China’s commercial aviation industry.Together, Boeing and China committed to further advance development of China’s commercial aviation industry and meet strategic business objectives for Boeing in the world’s largest airplane market going forward.President Xi, accompanied by Boeing executives, viewed final assembly lines for the 787 Dreamliner, 777 and 747-8, as well as aircraft components made by Chinese aviation suppliers. The president also spoke with Boeing employees and the 787 chief pilot about their work on airplanes built for Chinese carriers.Boeing President and CEO Dennis Muilenburg said Boeing appreciated China’s continued trust and confidence. “Today’s visit by President Xi represents a new chapter in the valuable relationship between Boeing and China,” Muilenburg said. “Boeing is committed to further strengthening and deepening our partnership with China in mutually beneficial ways that will bring positive outcomes to Boeing and our Chinese partners.”“Boeing will continue to work closely with our customers, suppliers and other stakeholders in China to support the long-term growth of China’s aviation industry and jobs here in the United States,” said Boeing Commercial Airplanes President and CEO Ray Conner. Learn more hereSource = Boeing
October 8, 2001The construction crew, September workshoppers and volunteers poured the stairsleading to the second floor of Phase V of the East Crescent Construction.[Photo by: Tomiaki Tamura] Since it was a small quantity pour, the group used the small mixer and carted it up to the formwork by hand.Pictured: Yeonsook bringing buckets of concrete up the stairs.[Photos and text by: Jennifer Thornton] Construction Crew Leader Ray Shong, smooths the concrete into the formwork Habitat Manager David Tollas, and the Construction crew, hosted a barbeque in Phase Five to celebrate the completion of thefirst floor which is the culmination of over a year of hard work by Arcosanti staff, volunteers and workshoppers.Pictured: Aldo fires up the BBQ while people check out the new stairs (back).
Health officials are investigating an outbreak of intestinal illness that has sickened dozens and is “likely linked” to salads at McDonald’s.McDonald’s said Friday it’s voluntarily pulling salads from about 3,000 locations in 14 states, primarily in the Midwest, until it can switch to a different lettuce supplier.The Centers for Disease Control and Prevention says it’s found 61 cases of cyclosporiasis among people located in Iowa, Illinois, Minnesota, Missouri, Nebraska, South Dakota and Wisconsin who had eaten salads at McDonald’s.Two people have been hospitalized and no deaths are linked to the outbreak.Illinois’ health department said Thursday that it confirmed about 90 cases of cyclosporiasis since mid-May. The same day, an Iowa health official said the state found “15 Iowans who ate McDonald’s salads in late June to early July prior to getting ill.” The Food and Drug Administration says cyclosporiasis is associated with symptoms including: “diarrhea, with frequent, sometimes explosive, bowel movements. Other common symptoms include loss of appetite, weight loss, stomach cramps/pain, bloating, increased gas, nausea, and fatigue. Vomiting, body aches, headache, fever, and other flu-like symptoms may be noted.”Cyclosporiasis is caused by the microscopic Cyclospora cayetanensis parasite that can contaminate food or water, according to the FDA.The CDC said as of Friday, it confirmed 227 cases of cyclosporiasis in people in Iowa, Minnesota, Wisconsin and Michigan who consumed now-recalled Del Monte vegetable trays. Del Monte recalled the trays in early June, the FDA says, and the agency says the Del Monte outbreak is not related to the one involving McDonald’s.Sickness caused by Cyclospora is “relatively rare in the U.S.” according to NPR’s Michaeleen Doucleff. “Most food poisonings here are caused by bacteria or viruses, like E. coli and norovirus. In contrast, Cyclospora is a protozoan, which typically hangs out in tropical and subtropical regions.”Standard treatment of sulfa drugs can “wipe out the infection quickly,” Doucleff notes. The CDC says most people with healthy immune systems will recover from Cyclospora infection without treatment, though health officials recommend anyone with diarrhea that has lasted more than three days to contact a health care provider. Copyright 2018 NPR. To see more, visit http://www.npr.org/.
Source:http://www.csic.es/ Reviewed by James Ives, M.Psych. (Editor)Feb 8 2019The details regarding the validation of this new device are published in the latest issue of Scientific Reports.Multifocal lenses are used in cataract surgeries – to replace the crystalline when it has lost its transparency – or to correct for presbyopia. There are different lens designs in the market, and choosing one or another depends on each patient’s tolerance and preference.”The possibility of the patient experimenting vision with a multifocal lens before the surgery is very attractive to reduce uncertainty and to manage expectations”, ensures CSIC researcher Susana Marcos, who works at the Institute of Optics. Her team at the Visual Optics and Biophotonics Laboratory has spent years developing technologies of simultaneous vision simulation aiming at evaluating visual quality with new designs of multifocal lenses before they are implanted or even manufactured.Related StoriesBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryResearchers use AI to develop early gastric cancer endoscopic diagnosis systemNew therapy shows promise in preventing brain damage after traumatic brain injuryNow, they are introducing SimVis, a lightweight binocular visual simulator which is autonomous and wearable in helmets. In the article, scientists show the equivalence between the vision provided by their device and the intraocular lenses. In other words, lenses are depicted in the simulator.A realistic experience”Visual simulators are an ideal technique to provide patients with a new realistic experience of multifocality before the implantation of a new intraocular lens. In addition, if the simulator is miniaturized and has a more practical design than the ones currently available in the market, benefits could multiply”, adds Marcos.Researchers validated the simulator’s realism in a group of patients by comparing the visual acuity obtained at different distances through a commercial trifocal lens – with focal points for close, intermediate and long focal distances – and through the same lens simulated by a spatial light modulator (another simulating technology) and by SimVis . “The response to multifocality depends on the subjects, but the real trifocal lens and the simulated one offered the same visual response through-focus in each patient”, concludes CSIC researcher María Viñas, first author of the article.The new simulator can be wirelessly controlled by a mobile application or a tablet. With this program it is possible not just controlling the device’s lenses, but also to track the functional tests conducted on each patient wherever they are.The technology developed by this group of CSIC scientists is protected by four patents – one of them received the award “Premio a la Mejor Patente del Año” from the Madrid+d Foundation – owned by CSIC, and licensed to the company 2EyesVision S.L., a spin-off founded, among others, by some of the study researchers.
ALS, also known as Lou Gehrig’s disease, affects more than 20,000 Americans. Currently, there are no effective treatments for ALS, largely due to poor understanding of how the disease initiates and progresses at the molecular level. The disease is invariably fatal. Source:University of California – San DiegoJournal reference:Fang, M. et al. (2019) Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. doi.org/10.1016/j.neuron.2019.05.048 While these findings still need to be tested in model organisms and there is more work to do before a potential therapy could one day be tested in patients, these compounds already expand our toolbox for unraveling the relationship between RNA-protein aggregations and neurological disease.”Mark Fang, PhD, Study First Author, UC San Diego Reviewed by James Ives, M.Psych. (Editor)Jul 2 2019Amyotrophic lateral sclerosis (ALS) is a neurological condition that affects motor neurons — the nerve cells that control breathing and muscles. Under a microscope, researchers have noticed that the motor neurons of patients with ALS contain excessive aggregation of a protein called TDP-43. Since TDP-43 proteins stuck in these aggregates can’t perform their normal function, the scientists believe this build-up contributes to motor neuron degeneration, the hallmark of ALS.In a study publishing July 1, 2019 in Neuron, UC San Diego School of Medicine researchers discovered that prolonged cellular stress, such as exposure to toxins, triggers TDP-43 clumping in the cytoplasm of human motor neurons grown in a laboratory dish. Even after the stress is relieved, TDP-43 clumping persists in ALS motor neurons, but not in healthy neurons.The team then screened and identified chemical compounds (potential precursors to therapeutic drugs) that prevent this stress-induced, persistent TDP-43 accumulation. These compounds also increased the survival time of neurons with TDP-43 proteins containing an ALS-associated mutation.”These compounds could provide a starting point for new ALS therapeutics,” said senior author Gene Yeo, PhD, professor at UC San Diego School of Medicine and faculty member in the Sanford Consortium for Regenerative Medicine.Yeo and team, including first author Mark Fang, PhD, who was a graduate student in Yeo’s lab at the time, generated motor neurons from induced pluripotent stem cells (iPSCs) that had been converted from human skin cells. To mimic cellular aspects of ALS, they exposed these laboratory motor neurons to toxins such as puromycin, which stressed the cells and led to TDP-43 clumps.Related StoriesScientists discover hundreds of protein-pairs through coevolution studyNew protein target for deadly ovarian cancerQuorn protein stimulates muscle building to a greater extent than milk proteinNormally, TDP-43 proteins help process molecules called messenger RNA, which serve as the genetic blueprints for making proteins. But when they clump outside the nucleus, TDP-43 proteins can’t perform their normal duty, and that can have a profound effect on many cellular functions.The researchers tested thousands of chemical compounds for their effects on RNA-protein aggregation. They were surprised to find compounds that not only reduced the overall amount of clumping by up to 75 percent, but also varied clump size and number per cell.Some of the compounds tested were molecules with extended planar aromatic moieties — arms that allow them to insert themselves in nucleic acids, such as DNA and RNA. TDP-43 must bind RNA in order to join ALS-associated clumps. Thus, according to Yeo, it makes sense that a compound that interacts with RNA would prevent TDP-43 from clumping.